Citation

Watier-Grillot S, Larréché S, Mazuet C, Baudouin F, Feraudet-Tarisse C, Holterbach L, Dia A, Tong C, Bourget L, Hery S, Pottier E, Bouilland O, Tanti M, Mérens A, Simon S, Diancourt L, Chesnay A, Pommier de Santi V. Toxins (Basel) 2023; 15(7): e457.

Copyright

(Copyright © 2023, MDPI: Multidisciplinary Digital Publishing Institute)

DOI

10.3390/toxins15070457

PMID

37505726

Abstract

On 6 July 2018, the Center for Epidemiology and Public Health of the French Armed Forces was informed of an outbreak of acute gastroenteritis among customers of a dining facility at a military base in Brittany, France. A total of 200 patients were reported out of a population of 1700 (attack rate: 12%). The symptoms were mainly lower digestive tract disorders and occurred rapidly after lunch on 5 July (median incubation period: 3.3 h), suggesting a toxin-like pathogenic process. A case-control survey was carried out (92 cases and 113 controls). Statistical analysis pointed to the chili con carne served at lunch on 5 July as the very likely source of poisoning. Phytohaemagglutinin, a plant lectin, was found in the chili con carne at a concentration above the potentially toxic dose (400 HAU/gram). The raw kidney beans incorporated in the chili con carne presented a high haemagglutination activity (66,667 HAU/gram). They were undercooked, and the phytohaemagglutinin was not completely destroyed. FBDOs due to PHA are poorly documented. This study highlights the need to develop methods for routine testing of plant toxins in food matrices. Improved diagnostic capabilities would likely lead to better documentation, epidemiology, and prevention of food-borne illnesses caused by plant toxins.

Language: en

Keywords

Clostridium perfringens; foodborne outbreak; lectin; Phaseolus vulgaris; phytohaemagglutinin; red kidney bean; toxin