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Abstract
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OBJECTIVE: To assess the association between ACEs and the development of psychiatric disorders by age 25 among individuals who sustained TBI prior to age 10.
DESIGN: Population-based case-control study. SETTING: Olmsted County, Minnesota.
PARTICIPANTS: 566 individuals who sustained a TBI prior to age 10 were identified and classified using a validated TBI classification system. Among these individuals, cases with a subsequent mood or anxiety disorder prior to age 25 were identified through clinical diagnostic codes and manual record review. For each case, a 1:1 matched control was randomly selected from individuals with a pediatric TBI who did not have a mood/anxiety disorder prior to the matched case's mood/anxiety disorder.
INTERVENTIONS: Not applicable
MAIN OUTCOME: Measure(s): Development of a mood/anxiety disorder.
RESULTS: Among the 114 matched pairs of individuals with a TBI prior to age 10, a subsequent mood/anxiety diagnosis was significantly associated with a history of 10 of 14 ACE categories and with having an ACE score ≥1 (OR 5.17; 95% CI 2.78-9.59).
CONCLUSION(S): This is the first population-based study to the authors' knowledge showing that among children who sustained a TBI prior to age 10, those who experienced ACEs are at increased risk of developing a mood or anxiety disorder.
Language: en |