|
Citation
|
Wang YP, Zhang B, Wang HE, Bai YM, Tsai SJ, Chen TJ, Chen MH. Dis. Colon Rectum 2023; ePub(ePub): ePub. |
|
Abstract
|
BACKGROUND: Evidence suggests that inflammatory bowel disease is related to an increased risk of depressive disorder and suicide.
OBJECTIVES: However, whether inflammatory bowel disease is an independent risk factor for suicide remains unclear.
DESIGN: A matched cohort study design. SETTINGS: Taiwan National Health Insurance Research Database. PATIENTS: A total of 3,625 adults with inflammatory bowel disease aged ≥20 years and 36,250 matched controls were selected between 1997 and 2013 and followed up to the end of 2013. MAIN OUTCOME MEASURES: Any suicide attempt was identified during the study period. Stratified Cox regression analysis was conducted on each matched pair to investigate the attempted suicide risk between the inflammatory bowel disease and control groups.
RESULTS: The hazard ratio for any suicide attempt among the patients with inflammatory bowel disease was 4.61 (95% CI: 3.29-6.48) compared with controls matched exactly for depressive disorder. No significant difference in suicide attempts was noted between patients with ulcerative colitis (hazard ratio: 4.12, 95% CI: 2.69-6.32) and Crohn's disease (hazard ratio: 5.78, 95% CI: 3.27-10.22). LIMITATIONS: The incidence of any suicide attempt may be underestimated.
CONCLUSION: Inflammatory bowel disease was an independent risk factor for attempted suicide. However, further studies are required to elucidate the definite pathomechanisms between IBD and suicide.
Language: en |