Citation

Otsuka M, Yamaguchi A, Miyaguchi H. Forensic Toxicol. 2022; ePub(ePub): ePub.

Copyright

(Copyright © 2022, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s11419-022-00656-4

PMID

unavailable

Abstract

The detection of hydrolysis products of Novichok agents in biological samples from victims is important for confirming exposure to these agents. However, Novichok agents are new class of nerve agent and there have been only few reports on analyses of Novichok agent degradation products. Here, we developed hydrophilic interaction liquid chromatography (HILIC)-tandem mass spectrometry (MS/MS) methods to detect Novichok agent degradation products in human urine with simple pretreatment and high sensitivity.

Language: en

Keywords

Biological fluids; HILIC–MS/MS; Nerve agents; Novichok agents; Warfare agents