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Abstract
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Clinical Question
In patients at risk of suicide who are admitted to a hospital, does ketamine (Ketalar) reduce suicidal ideation?
Bottom Line
Ketamine can rapidly reduce suicidal ideation and, presumably, the risk of suicide in at-risk patients voluntarily admitted to a hospital. However, based on this small study, ketamine does not seem to reduce the subsequent risk of attempted suicide over the next six weeks. (Level of Evidence = 1b−)
Synopsis
The researchers from seven hospitals in France enrolled 156 adults who were voluntarily admitted to a hospital for suicidal ideation with a score of more than 3 on the Beck scale for suicidal ideation. The patients, who did not have a history of substance use or psychotic disorders, were randomly assigned using concealed allocation to receive two 40-minute ketamine infusions, 0.5 mg per kg, or saline placebo infusions, given 24 hours apart. Using intention-to-treat analysis, remission of suicidal ideation at three days...
https://www.aafp.org/pubs/afp/issues/2022/0900/poems-ketamine-suicidal-ideation.html
Language: en |