Citation

Goldstein MR, Mascitelli L. Neurosci. Biobehav. Rev. 2022; ePub(ePub): ePub.

Copyright

(Copyright © 2022, Elsevier Publishing)

DOI

10.1016/j.neubiorev.2022.104785

PMID

35870652

Abstract

Regarding the interesting paper in this Journal (https://doi.org/10.1016/j.neubiorev.2022.104606), Costanza and coauthors mentioned the increase in suicidal ideation and suicidal behavior reported during the initial phase of the Coronavirus Disease 2019 (COVID-19) pandemic and that it possibly was related to various psychosocial factors and pre-existing psychiatric illness, while the increase in suicide risk seen during later phases of the pandemic was fueled by a pathological hyperinflammatory state, initiated by the virus causing COVID-19, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As such, SARS-CoV-2 activated macrophages and mast cells in the periphery and macrophages and glial cells in the brain release a myriad of inflammatory factors including IL1, IL6, and TNFα. Moreover, the authors pointed out that a similar inflammatory signature has been associated with suicide risk and posited that neuroinflammation from COVID-19 is overlapped with that of suicide pathophysiology. However, can we better identify those at higher risk for COVID-19 associated suicide?....

Language: en

Keywords

suicide; COVID-19; air pollution; ApoE4; lithium; neuroinflammation