Citation

Sadat-Shirazi MS, Sadeghi-Adl M, Akbarabadi A, Ashabi G, Mokri A, Zarrindast MR. CNS Neurol. Disord. Drug Targets 2022; ePub(ePub): ePub.

Copyright

(Copyright © 2022, Bentham Science Publishers)

DOI

10.2174/1871527321666220429122819

PMID

35507779

Abstract

Drug addiction is a chronic relapsing disorder that makes it a global problem. Genetics and environmental factors are the two most important factors that make someone vulnerable to drug addiction. Investigations in the past decade highlighted the role of epigenetics in the inter/transgenerational inheritance of drug addiction. A growing body of evidence showed that parental (paternal, maternal, and biparental) drug exposure before conception changes the phenotype of the offspring, which is correlated with neurochemical and neurostructural changes in the brain. In the current paper, the effects of parental (maternal, paternal, and biparental) exposure to drugs of abuse (opioids, cocaine, nicotine, alcohol, and cannabis) before gestation in animal models are reviewed.

Language: en

Keywords

cannabis; ethanol; nicotine; cocaine; opioid; parental.; Transgeneration