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Abstract
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See corrigendum at DOI: 10.1016/j.jsxm.2022.09.001
The relationship between mood disturbances and testosterone (T) levels is still conflicting and has not yet been completely clarified. Some observational studies have documented a weak association between male hypogonadism and the development of depressive symptoms, including major depressive disorder. Data from the Health In Men Study, a 9-year prospective study enrolling a community representative cohort of 3,179 older men free of clinically significant depressive symptoms at baseline, showed that low serum total T (<6.4 nmol/L), at enrolment, was associated with a 2-fold increased risk of developing incident depression even after the adjustment for confounders. Similar results were derived from a 2-year prospective study involving 278 American veterans older than 45 years. In line with these findings, a meta-analysis, including 18 studies among 168,756 individuals, found that androgen deprivation therapy in patients with prostate cancer was associated with a 41% increased risk of depression. In apparent contrast with this evidence, cross-sectional data from the European Male Aging Study, a population-based survey involving more than 3,400 subjects older than 40 years, did not report any association between mass-derived T levels, and several psychological symptoms including sadness, loss of energy, and fatigue...
Language: en |