Citation

Lv H, Zhang X, Wang J, Hou Z, Wang H, Li C, Wang W, Chen W, Zhang Y. Sci. Rep. 2022; 12(1): 6528.

Copyright

(Copyright © 2022, Nature Publishing Group)

DOI

10.1038/s41598-022-10531-2

PMID

35444225

Abstract

This study aimed to investigate the association between COVID-19 and fracture risk and provide a targeted reference for the world through China's experience. A nationally representative sample of COVID-19 prevalence areas selected using stratified random sampling was retrospectively analyzed. Age, sex, fracture site, mechanism of injury, and concurrent fractures of traumatic fracture patients in selected hospitals were collected from 10 January to 10 July 2020. The epidemiologic characteristics of traumatic fractures and the association between COVID-19 and fracture risk were explored using descriptive epidemiological methods and a distributed lag nonlinear model. A total of 67,249 patients (52.3% males, 49.4 ± 19.4 years old) with 68,989 fractures were included. The highest proportion of fractures were in the tibia and fibula (14.9%), followed by the femur (13.6%) and ulna and radius (12.5%). Low-energy fractures accounted for 23.3%. With the increase in newly confirmed COVID-19 cases, fracture risk decreased for children, young and middle-aged adults, elderly men, high-energy fractures, and residents in regions with < 1000 cumulative confirmed COVID-19 cases. Fracture risk decreased sharply in all residents except elderly women, for low-energy fractures, and in regions with > 1000 cumulative confirmed COVID-19 cases when newly confirmed COVID-19 cases increased in China. Primary (home) prevention measures are emphasized to prevent traumatic fractures.

Language: en

Keywords

Adult; Aged; Child; Humans; Female; Male; Middle Aged; Incidence; Retrospective Studies; *COVID-19/epidemiology; China/epidemiology; *Fractures, Bone/epidemiology/etiology; Cities/epidemiology