Citation

Jgamadze D, Johnson VE, Wolf JA, Cullen DK, Song H, Ming GL, Smith DH, Chen HI. Curr. Opin. Biomed. Eng. 2020; 14: 52-58.

Copyright

(Copyright © 2020, Elsevier Publishing)

DOI

10.1016/j.cobme.2020.05.004

PMID

35434439

PMCID

PMC9009274

Abstract

Traumatic brain injury (TBI) remains a prominent public health concern despite several decades of attempts to develop therapies for the associated neurological and cognitive deficits. Effective models of this condition are imperative for better defining its pathophysiology and testing therapeutics. Human brain organoids are stem cell-derived neural tissues that recapitulate many of the steps of normal neurodevelopment, resulting in the reproduction of a substantial degree of brain architecture. Organoids are highly relevant to clinical conditions because of their human nature and three-dimensional tissue structure, yet they are easier to manipulate and interrogate experimentally than animals. Thus, they have the potential to serve as a novel platform for studying TBI. In this article, we discuss available in vitro models of TBI, active areas of inquiry on brain organoids, and how these two concepts could be merged.

Language: en

Keywords

Traumatic brain injury; Brain organoids; Neurodegeneration; Stem cells