Citation

Meehan-Atrash J, Rahman I. Chem. Res. Toxicol. 2021; ePub(ePub): ePub.

Copyright

(Copyright © 2021, American Chemical Society)

DOI

10.1021/acs.chemrestox.1c00388

PMID

34889611

Abstract

Cannabis e-cigarettes containing Δ(8)-tetrahydrocannabinol (Δ(8)-THC) produced synthetically from hemp-derived cannabidiol (CBD) have recently risen in popularity as a legal means of cannabis consumption, but questions surrounding purity and unlabeled additives have created doubts of their safety. Herein, NMR, GC-MS, and ICP-MS were used to analyze major components of 27 products from 10 brands, and it was determined none of these had accurate Δ(8)-THC labeling, 11 had unlabeled cutting agents, and all contained reaction side-products including olivetol, Δ(4(8))-iso-tetrahydrocannabinol, 9-ethoxyhexahydrocannabinol, Δ(9)-tetrahydrocannabinol (Δ(9)-THC), heavy metals, and a novel previously undescribed cannabinoid, iso-tetrahydrocannabifuran.

Language: en