Citation

Dhanarisi J, Tzotzolaki TM, Vasileva AMD, Kjellberg MA, Hakulinen H, Vanninen P, Gawarammana I, Mohamed F, Hovda KE, Eddleston M. Basic Clin. Pharmacol. Toxicol. 2021; ePub(ePub): ePub.

Copyright

(Copyright © 2021, Nordic Pharmacological Society, Publisher John Wiley and Sons)

DOI

10.1111/bcpt.13686

PMID

34796663

Abstract

Self-poisoning with organophosphorus (OP) insecticides is an important means of global self-harm. The insecticides are formulated with solvents that may also contribute to toxicity. We set up a study to detect changes in osmolal and anion gaps following ingestion of OP insecticides. We recruited consecutive patients admitted to a Teaching Hospital, Sri Lanka, with a history of OP self-poisoning. The osmolal and anion gaps were calculated on admission and at 4, 24 and 72 h post-ingestion together with ethanol concentration. Forty-nine patients were recruited (28 profenofos, 10 diazinon, 1 coumaphos, 1 chlorpyrifos, 1 phenthoate, and 8 unknown OP). Only modest increases in osmolal and anion gaps were noted. Small rises in osmolal gap above the upper limit of normal were noted in 16/49 (32.7%) of all cases, 9/28 (32.1%) profenofos cases, and 4/10 (40.0%) diazinon cases. The anion gap was raised in 24/49 (49.0%) of all cases, 15/28 (53.6%) profenofos cases, and 5/10 (50.0%) diazinon cases. We observed a trend for a fall in osmolal gap during the first 24 h, followed by an increase up to 72 h. There was no correlation between the anion gap and serum lactate concentration, indicating that a lactic acidosis was not responsible for the anion gap. Formate, which could have explained the increased gap, was not detected in any of the samples; ketoacids (beta-hydroxy butyrate and acetoacetate) were not measured. This pilot study found that profenofos and diazinon poisoning caused only modest increases in the osmolal and anion gaps in a minority of cases.

Language: en

Keywords

Poisoning; Anion gap; Diazinon; Osmolal gap; Profenofos