Citation

Nourelahi M, Dadboud F, Khalili H, Niakan A, Parsaei H. Acute Crit. Care 2021; ePub(ePub): ePub.

Copyright

(Copyright © 2021, Korean Society of Critical Care Medicine)

DOI

10.4266/acc.2021.00486

PMID

34762793

Abstract

Traumatic brain injury (TBI), which occurs commonly worldwide, is among the more costly of health and socioeconomic problems. Accurate prediction of favorable outcome in severe TBI patients could assist with optimizing treatment procedures, predicting clinical outcomes, and result in substantial economic savings. In this study, we examined the capability of a machine learning-based model in predicting "favorable" or "unfavorable" outcome after 6 months in severe TBI patients using only parameters measured on admission. Three models were developed using logistic regression, random forest, and support vector machines trained on parameters recorded from 2,381 severe TBI patients admitted to the neuro-intensive care unit of Rajaee (Emtiaz) Hospital (Shiraz, Iran) between 2015 and 2017. Model performance was evaluated using three indices: sensitivity, specificity, accuracy, and area under the curve (AUC). Ten-fold cross-validation method was used to estimate these indices. Overall, the developed models showed excellent performance with AUC >0.81, sensitivity and specificity of > 0.78. The top-three factors important in predicting 6-month post-trauma survival status in TBI patients are "GCS motor response," "pupillary reactivity," and "age." Machine learning techniques might be used to predict the 6-month outcome in TBI patients using only the parameters measured on admission when the machine learning is trained using a large data set.

Language: en

Keywords

traumatic brain injury; artificial intelligence; favorable outcome; neuromonitoring; neurotrauma