Citation

Joyal CC, Putkonen A, Mancini-Marïe A, Hodgins S, Kononen M, Boulay L, Pihlajamaki M, Soininen H, Stip E, Tiihonen J, Aronen HJ. Schizophr. Res. 2007; 91(1-3): 97-102.

Affiliation

Niuvanniemi Hospital, Kuopio, Finland. christian.joyal@uqtr.ca

Copyright

(Copyright © 2007, Elsevier Publishing)

DOI

10.1016/j.schres.2006.12.014

PMID

17291724

Abstract

The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz+APD+SUD) would present a different pattern of prefrontal functioning than seriously violent persons with Sz only. In support with the main hypothesis, frontal basal cortices were significantly less activated in persons with Sz+APD+SUD during the execution of a go/no-go task than in persons with Sz only and non-violent persons without a mental illness. In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz+APD+SUD group than in the Sz-only group.

Language: en