Citation

Kwon KY, Lee EJ, Lee M, Ju H, Im K. Geriatr. Gerontol. Int. 2021; ePub(ePub): ePub.

Copyright

(Copyright © 2021, Japan Geriatrics Society, Publisher John Wiley and Sons)

DOI

10.1111/ggi.14156

PMID

unavailable

Abstract

AIM: Clinical implications for motor phenotypes of Parkinson's disease (PD) remain to be further elucidated, particularly at the early stages of the disease. We aimed to compare the non-motor and fall-related features between tremor-dominant (TD) and postural instability-gait difficulty (PIGD) subtypes in patients with early PD.

METHODS: PD was categorized into TD, intermediate and PIGD types, according to the literature. Not only motor symptoms, but also non-motor symptoms for global cognition, depression, anxiety, fatigue and dysautonomia, were measured in detail. In addition, fall-related features, including a previous history of falls, fear of fall measurement and gait freezing were assessed.

RESULTS: In patients with early PD (disease duration no more than 5 years), 35 patients with TD-type PD and 31 patients with PIGD-type PD were finally evaluated for the study. Compared with the TD group, the PIGD group showed higher fatigue, gastrointestinal dysfunction and fall-related parameter scores. Moreover, the PIGD scores were significantly correlated with all of those symptoms.

CONCLUSIONS: Our findings suggest that PIGD is significantly linked to fatigue, gastrointestinal dysfunction and fall-related features during the early stages of PD. Geriatr Gerontol Int ••; ••: ••-•• Geriatr Gerontol Int 2021; ••: ••-••.

Language: en

Keywords

fall; motor subtype; non-motor symptom; Parkinson's disease