Citation

Seidemann R, Duek O, Jia R, Levy I, Harpaz-Rotem I. Chronic Stress (Thousand Oaks) 2021; 5: e2470547021996006.

Copyright

(Copyright © 2021, SAGE Publications)

DOI

10.1177/2470547021996006

PMID

33718742

Abstract

Post-traumatic stress disorder (PTSD) is a highly prevalent disorder and a highly debilitating condition. Although anhedonia is an important construct of the disorder, the relationship between PTSD and reward functioning is still under-researched. To date, the majority of research on PTSD has focused on fear: fear learning, maintenance, and extinction. Here we review the relevant literature-including clinical observations, self-report data, neuroimaging research, and animal studies-in order to examine the potential effects of post-traumatic stress disorder on the reward system. Our current lack of sufficient insight into how trauma affects the reward system is one possible hindrance to clinical progress. The current review highlights the need for further investigation into the complex relationship between exposure to trauma and the reward system to further our understandings of the ethology of PTSD.

Language: en

Keywords

PTSD; trauma; stress; anhedonia; emotional numbing; MDD; negative valence; positive valence; reward system