Citation

Katan EA. Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 2020; 120(11): 141-147.

Copyright

(Copyright © 2020, Media Sphera)

DOI

10.17116/jnevro2020120111141

PMID

33340309

Abstract

The article presents data from research literature on the neurobiological consequences of abuse and neglect in childhood. It is shown that early life stress affects the trajectory of brain development, changes the patterns of cognitive behavioral control and reception of rewards, potentially increasing the risk of substance misuse. The combination of this factor with an immature prefrontal cortex can dramatically increase the liability to the development of substance dependence.

Language: ru

Keywords

child abuse; child neglect; neurodevelopment; neuroimaging; substance use disorder