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Citation
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Barateau L, Lopez R, Chenini S, Pesenti C, Rassu AL, Jaussent I, Dauvilliers Y. Neurology 2020; ePub(ePub): ePub. |
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Abstract
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OBJECTIVES: To assess the frequency and determinants of depressive symptoms and suicidal thoughts in adults with narcolepsy type 1 (NT1) and controls, as well as the changes after NT1 management, and the risk factors of major depressive episode (MDE) and suicide risk (SR) in NT1.
METHODS: 297 patients with NT1 (age: 39±17 years, 172 drug-free) and 346 controls (age: 38±16 years) underwent a comprehensive clinical evaluation including the Beck Depression Inventory-II (BDI-II) self-questionnaire, with one item on suicidal thoughts. 101 drug-free patients with NT1 completed the BDI-II a second time, during treatment. In 162 patients with NT1, the face-to-face Mini International Neuropsychiatric Interview (MINI) was performed to formally diagnose current MDE and SR.
RESULTS: BDI-II total scores were higher in patients with NT1 than controls, and in untreated than treated patients. Patients with moderate-severe BDI-II scores (24.9%) were less educated, more frequently obese, had more severe narcolepsy symptoms, more autonomic dysfunctions, and poorer quality of life.
RESULTS were unchanged in models adjusted for NT1 medication intake. Suicidal thoughts were more frequent in untreated patients than controls (22.7% vs 12.4%). Patients with suicidal thoughts were more likely to be men, and with more severe narcolepsy symptoms. After narcolepsy management, BDI-II total score and suicidal thoughts decreased. MDE was diagnosed in 29 (18.1%) and SR in 27 patients (16.9%).
CONCLUSIONS: Depression, depressive symptoms, suicidal thoughts and SR were frequent in patients with NT1, especially without treatment, and were associated with NT1 severity. Depressive symptoms and suicidal thoughts improved after NT1 management.
Language: en |