Citation

Lee MR, Dukan E, Milne I. J. R. Coll. Physicians Edinb. 2020; 50(1): 80-86.

Copyright

(Copyright © 2020, Royal College of Physicians of Edinburgh)

DOI

10.4997/JRCPE.2020.121

PMID

32539046

Abstract

Although we are familiar with common British plants that are poisonous, such as Atropa belladonna (deadly nightshade) and Aconitum napellus (monkshood), the two most poisonous plants in the British Flora are Oenanthe crocata (dead man's fingers) and Cicuta virosa (cowbane). In recent years their poisons have been shown to be polyacetylenes (n-C2H2). The plants closely resemble two of the most common plants in the family Apiaceae (Umbelliferae), celery and parsley. Unwittingly, they are ingested by naive foragers and death occurs very rapidly. The third plant Anamirta derives from South-East Asia and contains a powerful convulsant, picrotoxin, which has been used from time immemorial to catch fish, and more recently to poison Birds of Paradise. All three poisons have been shown to block the γ-aminobutyric acid (GABA) system in the human brain that normally has a powerful inhibitory neuronal action. It has also been established that two groups of sedative drugs, barbiturates and benzodiazepines, exert their inhibitory action by stimulating the GABA system. These drugs are the treatments of choice for poisoning by the three vicious plants.

Language: en

Keywords

Anamirta; barbiturates; benzodiazepines; Cicuta; GABA; gamma-aminobutyric acid; Oenanthe; poisonous plants; transient loss of consciousness