Citation

Zhong N, Chen T, Zhu Y, Su H, Ruan X, Li X, Tan H, Jiang H, Du J, Zhao M. Front. Psychiatry 2020; 11: e320.

Affiliation

Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.

Copyright

(Copyright © 2020, Frontiers Media)

DOI

10.3389/fpsyt.2020.00320

PMID

32372989

PMCID

PMC7186331

Abstract

Methamphetamine (MA) chronic users show risky decision-making deficits. However, the neural mechanisms underlying these deficits remain unclear. A case-control study was conducted to understand how MA users and healthy controls differ in electrophysiological responses associated with series decision-making. Electroencephalography of 31 MA users and 27 healthy controls was recorded when they performed the Balloon Analogue Risk Task involving risky decision-making with uncertain gain or loss. Feedback-related negativity (FRN) was measured and their association with their risky decision-making and impulsivity were examined. Compared to healthy controls, MA users showed smaller peak FRN amplitudes in fronto-central electrodes (F _(1,56) =4.559, p=0.037), and the attenuated peak FRN amplitudes correlated with more risk-taking behavior (r=0.48, p=0.012). Besides, MA users exhibited later FRN (F _(1,56) = 7.561, p=0.008) and earlier P300 (F _(1,56) = 3.582, p = 0.041) compared to healthy controls in fronto-central electrodes, which were correlated with higher score of impulsivity. These findings provided further evidence that MA users showed insensitivity to negative feedback in risky decision-making. FRN might be a promising biomarker of dependence.

Copyright © 2020 Zhong, Chen, Zhu, Su, Ruan, Li, Tan, Jiang, Du and Zhao.

Language: en

Keywords

dependence; feedback-related negativity (FRN); impulsivity; methamphetamine; risky decision-making