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Citation |
Wan Z, Rolls ET, Cheng W, Feng J. Neuroimage 2020; ePub(ePub): ePub. |
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Affiliation |
Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, 200433, China; Department of Computer Science, University of Warwick, Coventry, CV4 7AL, UK; School of Mathematical Sciences, School of Life Science and the Collaborative Innovation Center for Brain Science, Fudan University, Shanghai, 200433, PR China. |
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Copyright |
(Copyright © 2020, Elsevier Publishing) |
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DOI |
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PMID |
32289458 |
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Abstract |
Sensation-seeking is a multifaceted personality trait with components that include experience-seeking, thrill and adventure seeking, disinhibition, and susceptibility to boredom, and is an aspect of impulsiveness. We analysed brain regions involved in sensation-seeking in a large-scale study with 414 participants and showed that the sensation-seeking score could be optimally predicted from the functional connectivity with typically (in different participants) 18 links between brain areas (measured in the resting state with fMRI) with correlation r=0.34 (p=7.3×10-13) between the predicted and actual sensation-seeking score across all participants. Interestingly, 8 of the 11 links that were common for all participants were between the medial orbitofrontal cortex and the anterior cingulate cortex and yielded a prediction accuracy r=0.30 (p=4.8×10-10). We propose that this important aspect of personality, sensation-seeking, reflects a strong effect of reward (in which the medial orbitofrontal cortex is implicated) on promoting actions to obtain rewards (in which the anterior cingulate cortex is implicated). Risk-taking was found to have a moderate correlation with sensation-seeking (r=0.49, p=3.9×10-26), and three of these functional connectivities were significantly correlated (p<0.05) with the overall risk-taking score. This discovery helps to show how the medial orbitofrontal and anterior cingulate cortices influence behaviour and personality, and indicate that sensation-seeking can involve in part the medial orbitofrontal cortex reward system, which can thereby become associated with risk-taking and a type of impulsiveness. Language: en |
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Keywords |
anterior cingulate cortex; functional connectivity; impulsivity; non-reward; orbitofrontal cortex; reward |