Citation

Stafford M, Cavanna AE. Neurosci. Biobehav. Rev. 2020; ePub(ePub): ePub.

Affiliation

Department of Neuropsychiatry, BSMHFT and University of Birmingham, Birmingham, United Kingdom; School of Life and Health Sciences, Aston University, Birmingham, United Kingdom; University College London and Institute of Neurology, London, United Kingdom. Electronic address: A.E.Cavanna@bham.ac.uk.

Copyright

(Copyright © 2020, Elsevier Publishing)

DOI

10.1016/j.neubiorev.2020.03.022

PMID

32205150

Abstract

Tourette syndrome (TS) is a neurodevelopmental condition characterized by the presence of multiple tics. In addition to common behavioral co-morbidities such as obsessive-compulsive disorder and attention-deficit and hyperactivity disorder, patients with TS can present with self-injurious behavior (SIB): deliberate, non-accidental, repetitive infliction of self-harm without suicidal intent. In order to determine the prevalence and clinical correlates of SIB in TS, we conducted a systematic literature review in accordance to the methodology described in the MOOSE Guidelines for Meta-Analysis and Systematic Reviews of Observational Studies in Epidemiology. The literature search yielded 20 cohort studies that were suitable for quantitative synthesis. Combined results showed that SIB is present in 35% of patients with TS. Obsessive-compulsive behaviors appear to be associated with SIB in patients with TS, and their presence should alert clinicians to the possible co-occurrence of SIB, particularly if the patient has multiple behavioral co-morbidities. Since the reviewed studies were methodologically heterogeneous and were conducted in specialist clinics, our findings cannot be generalized to patients with TS in the wider community.

Copyright © 2020. Published by Elsevier Ltd.

Language: en

Keywords

Tourette syndrome; obsessive-compulsive behaviors; prevalence; self-injurious behavior; tics