Citation

Aloi J, Blair KS, Meffert H, White SF, Hwang S, Tyler PM, Crum KI, Thornton LC, Mobley A, Killanin AD, Filbey FM, Pope K, Blair RJ. Addict. Biol. 2020; ePub(ePub): e12885.

Affiliation

Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, Nebraska.

Copyright

(Copyright © 2020, John Wiley and Sons)

DOI

10.1111/adb.12885

PMID

32135572

Abstract

Two of the most commonly used substances by adolescents in the United States are cannabis and alcohol. Cannabis use disorder (CUD) and alcohol use disorder (AUD) are associated with impairments in decision-making processes. One mechanism for impaired decision-making in these individuals is thought to be an inability to adequately represent future events during decision-making. In the current study involving 112 adolescents, we used a comparative optimism task to examine the relationship between relative severity of CUD/AUD (as indexed by the CUD/AUD Identification Tests [CUDIT/AUDIT]) and atypical function within neural systems underlying affect-based neural represenation future events. Greater CUDIT scores were negatively related to responses within subgenual anterior and posterior cingulate cortex when processing high-intensity potential future positive and negative events. There was also a particularly marked negative relationship between CUD symptoms and blood oxygen level-dependent (BOLD) responses within visual and premotor cortices to high-intensity, negatively valenced potential future events. However, AUD symptom severity was not associated with dysfunction within these brain regions. These data indicate that relative risk/severity of CUD is associated with reduced responsiveness to future high-intensity events. This may impair decision-making where future significant consequences should guide response choice.

© 2020 Society for the Study of Addiction.

Language: en

Keywords

adolescent; cannabis; fMRI