Citation

Huestis MA. Chem. Biodivers. 2007; 4(8): 1770-1804.

Copyright

(Copyright © 2007, Verlag Helvetica Chimica Acta AG, Zürich, Switzerland, Publisher John Wiley and Sons)

DOI

10.1002/cbdv.200790152

PMID

unavailable

Abstract

Cannabis is one of the oldest and most commonly abused drugs in the world, and its use is associated with pathological and behavioral toxicity. Thus, it is important to understand cannabinoid pharmacokinetics and the disposition of cannabinoids into biological fluids and tissues. Understanding the pharmacokinetics of a drug is essential to understanding the onset, magnitude, and duration of its pharmacodynamic effects, maximizing therapeutic and minimizing negative side effects...

An understanding of human cannabinoid pharmacokinetics is important for the development and monitoring of new therapeutic medications and to the interpretation of cannabinoid test results in a wide variety of biological matrices, including blood, plasma, urine, oral fluid, sweat, and hair. With the advent of new preparations containing THC, CBD, and other cannabinoids, and new administration routes, additional research is needed. Also, controlled drug-administration studies that provide the scientific database for interpreting cannabinoid concentrations in biological fluids and tissues are increasingly difficult to conduct due to safety and ethical concerns, and because of the high costs of performing human research. However, these data are essential for appropriate application of pharmacotherapies, and for drug testing in treatment, workplace, and forensic cases.

Keywords: Cannabis impaired driving

Language: en

Keywords

Cannabidiol; Cannabinoids; Cannabinol; Pharmacokinetics; Tetrahydrocannabinol (THC)