Citation

Castel P, Simon P, Barbier M, Sunyach C, Tassistro V, Manzoni O, Pelissier AL, Courbiere B. Gynecol. Obstet. Fertil. Senol. 2020; ePub(ePub): ePub.

Vernacular Title

Focus sur le système endocannabinoïde et la reprotoxicité du cannabis chez la femme à l’heure du débat sur sa dépénalisation en France.

Affiliation

Aix Marseille Univ, Avignon Université, CNRS, IRD, IMBE, Institut Méditerranéen de Biodiversité et d'Ecologie marine et continentale, Equipe Biomarqueurs, Environnement et Santé, Site Timone, 27 Bd Jean Moulin, 13005 Marseille, France; Pôle Femmes-Parents-Enfants, Plateforme Couple Reproduction Enfant: Environnement & Risque (CREER), AP-HM, Hôpital de La Conception- Hôpital Nord, Marseille, France.

Copyright

(Copyright © 2020, Elsevier Publishing)

DOI

10.1016/j.gofs.2020.01.024

PMID

32017991

Abstract

Among recreative compounds, marijuana is the most used worldwide. Delta9THC binding on brain endocannabinoid receptors drives its psychotropic effects. The endocannabinoid system (ECS) is an endogenous neurohormonal system essential for homeostasis composed of ligands, metabolic enzymes and at least 2 receptors discovered to date. In female reproduction, the ECS regulates the hypothalamic-pituitary axis and many steps of the reproduction process, such as ovulation, tubal transportation and trophoblast implantation. Delta9THC can cross the placental barrier and bind to the fetal endocannabinoid system. In humans, fetal and obstetrical consequences of marijuana use during pregnancy are intrauterine growth restriction and preterm delivery. In the light of legalization projects currently reviewed in several western countries, further research should be conducted to improve knowledge on maternal, fetal and reprotoxic consequences of marijuana use during reproductive age and pregnancy.

Copyright © 2020. Published by Elsevier Masson SAS.

Language: fr

Keywords

cannabis; endocannabinoid system; female reproduction; grossesse; marijuana; pregnancy; reproduction feminine; reprotoxicity; reprotoxicité; système endocannabinoïde