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Citation
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Yang D, Lian J, Wang L, Liu X, Wang Y, Zhao X, Zhang X, Hu W. Saudi J. Biol. Sci. 2019; 26(8): 2052-2056. |
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Affiliation
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Sub-center of Medicine and Food Homology and Health Research, National Engineering Research Center for Modernazation of Traditional Chinese Medicine, Zhuhai 519041, China. |
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Abstract
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OBJECTIVE: The present study intended to explore the anti-fatigue and anti-hypoxia efficacy of Tremella extract in mouse model.
METHODS: Kunming mice were randomized into 5 groups randomly (n = 12/group; half male and female), and given 0.9%Nacl (10 mL/Kg Serving as blank control group)orally, 0.6 g/kg rhodiola capsule (Serving as positive group) and Tremella extract at doses of high (3.0 g/kg), middle (1.5 g/kg) and low (0.5 g/kg) once a day for 14 days. At the end of drug intragastric gavage, following endurance running test, rotating rod test, normobarie hypoxia test and sodium nitrite poisoning test were performed.
RESULT: 14-day Tremella extract administration fails to influence mouse horizontal and vertical movement indicating little neurotoxicity at chosen doses. Through rotating rod, forced running test, the anti-fatigue activity of Tremella extract was demonstrated. Via normobarie hypoxia test, sodium nitrite poisoning test, Tremella extract was confirmed to possess anti-hypoxia effect. Tremella extract treatment significantly enhanced the liver levels of superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), increased the expressions of ATP and hepatic glycogen, muscle glycogen in tissue.
CONCLUSION: We conclude that Tremella extract efficiently enhances mouse fatigue endurance and anti-hypoxia capability partly through energy reserves and antioxidant enzyme activity.
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Language: en |