Citation

Paramanandam V, Olszewska DA, Shakya B, Chalissery AJ, O'Connell M, Farrell M, Lynch T. Mov. Disord. Clin. Pract. (Hoboken) 2019; 6(8): 656-660.

Affiliation

Centre for Brain Health Dublin Neurological Institute at the Mater Misericordiae University Hospital Dublin Ireland.

Copyright

(Copyright © 2019, John Wiley and Sons)

DOI

10.1002/mdc3.12825

PMID

31745473

PMCID

PMC6856468

Abstract

CLINICAL HISTORY: A 57-year old woman presented with left hand pain, periodic leg movement during sleep, gradual onset of stiffness, clumsiness, and falls. Neurological examination showed: generalized rigidity and bradykinesia. There was left hand dystonic posturing and ideomotor apraxia, as well as mirror movements of upper limbs and stimulus-sensitive myoclonus. The patient had a high-pitched voice and hypophonia (Video S1).

DISCUSSION: Experts discuss localization and the syndromic diagnosis and predict the underlying pathology. The pathological diagnosis is then provided and clinical learning points are considered.

© 2019 International Parkinson and Movement Disorder Society.

Language: en

Keywords

alpha‐synuclein; corticobasal syndrome; cytoplasmic inclusions; multisystem atrophy; myoclonus; parkinsonism