Citation

Polich G, Iaccarino MA, Zafonte R. Handb. Clin. Neurol. 2019; 165: 253-267.

Affiliation

Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA, United States. Electronic address: rzafonte@partners.org.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/B978-0-444-64012-3.00015-0

PMID

31727216

Abstract

The pathophysiology of traumatic brain injury (TBI) can be highly variable, involving functional and/or structural damage to multiple neuroanatomical networks and neurotransmitter systems. This wide-ranging potential for physiologic injury is reflected in the diversity of neurobehavioral and neurocognitive symptoms following TBI. Here, we aim to provide a succinct, clinically relevant, up-to-date review on psychopharmacology for the most common sequelae of TBI in the postacute to chronic period. Specifically, treatment for neurobehavioral symptoms (depression, mania, anxiety, agitation/irritability, psychosis, pseudobulbar affect, and apathy) and neurocognitive symptoms (processing speed, attention, memory, executive dysfunction) will be discussed. Treatment recommendations will reflect general clinical practice patterns and the research literature.

Copyright © 2019 Elsevier B.V. All rights reserved.

Language: en

Keywords

Anxiety; Attention; Depression; Memory; Neurobehavioral disorders; Neurocognitive disorders; Psychopharmacology; Traumatic brain injury