Citation

Résière D, Villalta M, Arias AS, Kallel H, Nèviére R, Vidal N, Mehdaoui H, Gutiérrez JM. Toxicon 2019; ePub(ePub): ePub.

Affiliation

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica;. Electronic address: jose.gutierrez@ucr.ac.cr.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.toxicon.2019.11.001

PMID

31726079

Abstract

Snakebite envenoming is a relevant public health problem in French Guiana, and Bothrops atrox is responsible for the vast majority of envenomings in this overseas French territory. The preclinical efficacy of freeze-dried antivenoms manufactured in Costa Rica (Polival-ICP®) and Mexico (Antivipmyn Tri®) was assessed against the lethal, hemorrhagic, in vitro coagulant, and myotoxic effects of Bothrops atrox venom from French Guiana. Antivenoms differ in protein concentration and in the type of active principle (IgG and F(ab')₂, respectively). Polival-ICP® showed significantly higher neutralizing activity against lethal, hemorrhagic and in vitro coagulant activities of the venom. Antivenoms neutralized myotoxic effect to a similar extent. In the case of lethal activity, Antivipmyn Tri® did not neutralize the effect at the highest antivenom level tested (1 mg venom/mL antivenom).

Copyright © 2019. Published by Elsevier Ltd.

Language: en

Keywords

Antivipmyn Tri®; French Guiana; Polival-ICP®; Snake venoms; antivenom; neutralization; preclinical efficacy