Citation

Thibeault CM, Thorpe S, Canac N, O'Brien MJ, Ranjbaran M, Wilk SJ, Hamilton RB. J. Concussion 2019; 3: e2059700219838654.

Copyright

(Copyright © 2019, SAGE Publishing)

DOI

10.1177/2059700219838654

PMID

unavailable

Abstract

There is an unquestionable need for quantitative biomarkers of mild traumatic brain injuries. Something that is particularly true for adolescents - where the recovery from these injuries is still poorly understood. However, within this population, it is clear that the vasculature is distinctly affected by a mild traumatic brain injury. In addition, our group recently demonstrated how that effect appears to show a progression of alterations similar but in contrast to that found in severe traumatic injuries. Through measuring an adolescent population with transcranial Doppler ultrasound during a hypercapnia challenge, multiple phases of hemodynamic dysfunction were suggested. Here, we create a generalized model of the hemodynamic responses by fitting a set of inverse models to the dominant features from that work. The resulting model helps define the multiple phases of hemodynamic recovery after a mild traumatic brain injury. This can eventually be generalized, potentially providing a diagnostic tool for clinicians tracking patient's recovery, and ultimately, resulting in more informed decisions and better outcomes.

Language: en

Keywords

Traumatic brain injury,vascular reactivity, cerebral blood flow autoregulation, blood flow, cerebral blood flow velocity