Citation

Weil ZM, Karelina K. Front. Neuroendocrinol. 2019; ePub(ePub): ePub.

Affiliation

Department of Neuroscience, Group in Behavioral Neuroendocrinology, Center for Brain and Spinal Cord Repair, The Ohio State University Wexner Medical Center, Columbus OH, U.S.A. 43210.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.yfrne.2019.100793

PMID

31560884

Abstract

Traumatic brain injuries in children represent a major public health issue and even relatively mild injuries can have lifelong consequences. However, the outcomes from these injuries are highly heterogeneous, with most individuals recovering fully, but a substantial subset experiencing prolonged or permanent disabilities across a number of domains. Moreover, brain injuries predispose individuals to other kinds of neuropsychiatric and somatic illnesses. Critically, the severity of the injury only partially predicts subsequent outcomes, thus other factors must be involved. In this review, we discuss the psychological, social, neuroendocrine, and autonomic processes that are disrupted following traumatic brain injury during development, and consider the mechanisms the mediate risk or resilience after traumatic brain injury in this vulnerable population.

Copyright © 2019. Published by Elsevier Inc.

Language: en

Keywords

HPA axis; autonomic; pituitary dysfunction; resilience; risk; stress; traumatic brain injury