Citation

Matei HV, Vică ML, Ciucă I, Coman HG, Nicula GZ, Siserman CV. J. Forensic Sci. 2019; ePub(ePub): ePub.

Affiliation

Department of Legal Medicine, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 3-5 Clinicilor Street, 400 006, Cluj-Napoca, Romania.

Copyright

(Copyright © 2019, American Society for Testing and Materials, Publisher John Wiley and Sons)

DOI

10.1111/1556-4029.14166

PMID

31408207

Abstract

Suicide is a worldwide health problem with multiple causes, including genetic factors. The major histocompatibility complex (MHC) is represented by an assembly of gene encoding the human leukocyte antigen (HLA). The purpose of our study was to determine associations between the HLA profiles and predisposition for suicidal behavior. We harvested blood samples from persons with history of suicidal attempts (case group) and persons never exhibiting such behavior (control group). The DNA was extracted and amplified via polymerase chain reaction (PCR) to determine the HLA-DQB1 profiles. Statistical data processing was performed with the Epi Info program. We found that the presence of the HLA-DQB1*02 allele increases the risk of suicidal behavior, while HLA-DQB1*05 alleviates such risk. The genotype that presented the most increased risk for suicidal behavior was found to be HLA-DQB1*02/HLA-DQB1*03. Our study has demonstrated the presence of several associations between HLA profiles and suicidal behavior.

© 2019 American Academy of Forensic Sciences.

Language: en

Keywords

DNA typing; DQB1; forensic science; genotype; human leukocyte antigen; polymerase chain reaction; suicide