Citation

Tietbohl-Santos B, Chiamenti P, Librenza-Garcia D, Cassidy R, Zimerman A, Manfro GG, Kapczinski F, Passos IC. Neurosci. Biobehav. Rev. 2019; 105: 34-38.

Affiliation

Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Graduation Program in Psychiatry and Department of Psychiatry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Electronic address: ivescp1@gmail.com.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.neubiorev.2019.07.022

PMID

31376408

Abstract

BACKGROUND: Subjects with panic disorder are nearly 4 times as likely to attempt suicide as compared to subjects without this condition.

METHODS: We searched the literature from Jan 1, 1960 to May, 4, 2019. Articles that reported a dichotomous sample of patients with panic disorder with and without suicidal behavior were included. OUTCOMES: Twelve studies with 1958 participants were included. Comorbid depression (k = 3, ES = 4.47 [2.63; 7.60]), depressive symptoms (k = 2, ES = 1.98 [1.26; 3.11]), older age (k = 3, ES = 1.66 [1.32; 2.10]), younger age of panic disorder onset (k = 2, ES = 0.65 [0.45; 0.94]), and history of alcohol dependence (k = 2, ES = 8.70 [1.20; 63.04]) were associated with suicide attempt in panic disorder. Depressive symptoms (k = 2, ES = 2.29 (1.60; 3.37]), anxiety symptoms (k = 2, ES = 1.90 [1.33; 2.69]), longer illness duration (k = 2, ES = 3.31 [1.90; 5.74]), comorbid depressive disorder (k = 4, ES = 3.88 [2.03; 7.41]), agoraphobia (k = 2, ES = 4.60 [1.47; 14.42]) and younger age of onset (k = 2, ES = 0.60 [0.38; 0.96]) were associated with suicidal ideation in panic disorder.

INTERPRETATION: Our findings provide a framework for the development of suicide prevention strategies in this population.

Copyright © 2019. Published by Elsevier Ltd.

Language: en

Keywords

meta-analysis; panic disorder; risk factors; suicide