Citation

Fu S, Ma X, Li C, Wang T, Li C, Bai Z, Hua K, Yin Y, Wu Y, Yu K, Liu M, Ke Q, Tian J, Jiang G. Neuroimage (Amst) 2019; 24: e101951.

Affiliation

The Second School of Clinical Medicine, Southern Medical University, People's Republic of China; The Department of Medical Imaging Guangdong Second Provincial General Hospital, Southern Medical University, People's Republic of China. Electronic address: jiangguihua1970@163.com.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.nicl.2019.101951

PMID

31374398

Abstract

OBJECTIVES: The present study explored the changes in spontaneous regional activity in post-traumatic stress disorder (PTSD) patients, who experienced severe traffic accidents.

METHODS: 20 drug-naive PTSD patients and 18 healthy control subjects were imaged using resting-state functional magnetic resonance imaging (rs-fMRI) and analyzed by the algorithm of regional homogeneity (ReHo).

RESULTS: Compared to the healthy control group, the PTSD group showed decreased ReHo values in the right angular gyrus. In addition, a negative correlation was found between the activity level of the angular gyrus and the CAPS score.

CONCLUSION: The dysfunctions were found in the memory- and emotion-related areas, suggested a possible mechanism of memory dysregulation that might be related to the intrusive memory symptoms of PTSD. These results provided imaging evidence that might provide an in-depth understanding of the intrinsic functional architecture of PTSD.

Copyright © 2019. Published by Elsevier Inc.

Language: en

Keywords

Angular gyrus; PTSD; Traffic accidents; fMRI