Citation

Berardelli I, Belvisi D, Nardella A, Falcone G, Lamis DA, Fabbrini G, Berardelli A, Girardi P, Pompili M. CNS Neurol. Disord. Drug Targets 2019; ePub(ePub): ePub.

Affiliation

Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome. Italy.

Copyright

(Copyright © 2019, Bentham Science Publishers)

DOI

10.2174/1871527318666190703093345

PMID

31269887

Abstract

BACKGROUND: Psychiatric disorders and suicide have been reported in patients suffering from Parkinson's disease. The aims of the present paper were to determine whether patients with Parkinson's disease have an increased rate of suicide and to identify the clinical features possibly associated with suicide risk in Parkinson's disease. We also revised the studies on suicide risk in Parkinson's disease patients after deep brain stimulation.

METHODS: We performed a MedLine, Excerpta Medica, PsycLit, PsycInfo and Index Medicus search to identify all articles published on this topic from 1970 to 2017. The following search terms were used: suicide OR suicide attempt OR suicidal ideation OR suicide risk AND Parkinson's disease AND Parkinson's disease and deep brain stimulation.

RESULTS: The studies we identified that assessed the suicide rate associated with Parkinson's disease yielded contrasting results, although an increase in suicidal ideation did emerge. The studies on the effect of deep brain stimulation on suicide risk in Parkinson's disease also reported controversial findings. Psychiatric symptoms, including depression, appear to be associated with suicide risk in patients with Parkinson's disease on medical and after surgical treatment.

CONCLUSIONS: It is unclear whether there is an increased risk of suicide among patients with Parkinson's disease and whether suicide risk is increased by deep brain stimulation. Further studies designed to assess suicidality in this condition are therefore warranted.

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Language: en

Keywords

Parkinson’s disease; deep brain stimulation ; suicidal ideation; suicide risk