Citation

Chen S, Mizoue T, Hu H, Kuwahara K, Honda T, Yamamoto S, Nakagawa T, Miyamoto T, Okazaki H, Shimizu M, Murakami T, Eguchi M, Kochi T, Yamamoto M, Ogasawara T, Sasaki N, Uehara A, Imai T, Nishihara A, Hori A, Nagahama S, Tomita K, Konishi M, Kabe I, Dohi S. Acta Neuropsyciatr. 2019; ePub(ePub): 1-13.

Affiliation

eMitsui Chemicals, Inc.,Tokyo,Japan.

Copyright

(Copyright © 2019, Cambridge University Press)

DOI

10.1017/neu.2019.26

PMID

31258109

Abstract

OBJECTIVE: To investigate the association between suicide death and serum cholesterol levels as measured at times close to suicide death.

METHODS: We conducted a nested case-control study of 41 cases of suicide deaths and 205 matched controls with serum total cholesterol (TC) levels till three years before suicide death in a large cohort of Japanese workers.

RESULTS: Individuals in the lowest vs. highest tertile/predefined category of TC in a Japanese working population had a three- to four-fold greater risk of suicide death. Each 10 mg/dL decrement of average TC was associated with an 18% increased chance of suicide death (95% confidence interval, 2-35%). Similar results were found for TC levels at each year.

CONCLUSION: These results suggest that a low serum TC level in recent past is associated with an increased risk of suicide death.

Language: en

Keywords

cholesterol; nested case-control study; suicide; working population