Citation

Hirjak D, Kubera KM, Sambataro F, Wolf RC. Eur. Arch. Psychiatry Clin. Neurosci. 2019; ePub(ePub): ePub.

Affiliation

Department of General Psychiatry, Center for Psychosocial Medicine, Heidelberg University, Heidelberg, Germany.

Copyright

(Copyright © 2019, Holtzbrinck Springer Nature Publishing Group)

DOI

10.1007/s00406-019-01036-7

PMID

31240444

Abstract

We were very pleased to read the excellent article by Swets et al. [1], who examined longitudinally for 3 years motor (akathisia, dyskinesia, parkinsonism and dystonia) and obsessive compulsive symptoms (OCS) in psychotic patients and individuals with increased liability for psychosis: patients with psychotic disorders (n = 726) and their unaffected siblings (n = 761). At baseline, there was no relationship between any motor symptoms and OCS. At follow-up, the authors showed that patients with OCS reported more frequently akathisia. Although the overall severity of motor symptoms was low, unaffected siblings with OCS had higher risk of developing akathisia at baseline. Swets et al. [1] concluded that motor symptoms might precede co-occurring OCS in patients with psychotic disorders. The large sample size and the examination of unaffected relatives increase the significance of this study.

Nevertheless, there are several aspects of motor dysfunction in psychotic disorders...

Language: en

Keywords

Biomarkers; MRI; Motor symptoms; Neuroimaging; Obsessive-compulsive symptoms