Citation

Bartoli F, Crocamo C, Carrà G. Neurosci. Biobehav. Rev. 2019; 103: 14-20.

Affiliation

Department of Medicine and Surgery, University of Milano Bicocca, Monza, Italy; Department of Mental Health & Addiction, ASST Nord Milano, Milano, Italy; Division of Psychiatry, University College London, London, UK. Electronic address: giuseppe.carra@unimib.it.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.neubiorev.2019.05.017

PMID

31121199

Abstract

We aimed at clarifying the strength and consistency of the association between cannabis use disorder and suicide attempts in bipolar disorder. We conducted a systematic review and meta-analysis of observational studies providing cross-sectional and longitudinal data on the association between cannabis use disorder and suicide attempts in adults with bipolar disorder. We screened articles indexed in Medline, Embase, PsycINFO databases up to July 2018. The random-effects meta-analysis, based on 6,375 subjects from eleven studies, estimated a cross-sectional association between cannabis use disorder and history of suicide attempts (OR = 1.35; p = 0.01; I² = 41.7%). Meta-regression analyses showed that effect size was not influenced by any study characteristics. Publication bias was not detectable. We could not perform a meta-analysis exploring the longitudinal association between cannabis use disorder and suicide attempts, due to the lack of suitable data. The current evidence highlights a weak association between cannabis use disorder and suicidal attempts in bipolar disorder. Due to the cross-sectional design of included studies, causal inferences could not be explored.

Copyright © 2019. Published by Elsevier Ltd.

Language: en

Keywords

bipolar disorder; cannabis; meta-analysis; suicide