Citation

Toledo M, Mazuela G, Mauri JA, Rodriguez-Osorio X, Gómez-Eguilaz M, Castro-Vilanova D, Rodriguez-Uranga J, Santamarina E. Acta Neurol. Scand. 2019; 140(1): 48-55.

Affiliation

Epilepsy Unit. Neurology Department. Vall d'Hebron Hospital. Passeig Vall d'Hebron, 119-129. 08035, Barcelona. Spain.

Copyright

(Copyright © 2019, John Wiley and Sons)

DOI

10.1111/ane.13099

PMID

30953593

Abstract

INTRODUCTION: Aggressive behavior is commonly associated with epilepsy and, can be influenced by the antiepileptic drugs (AEDs) taken. Sodium channel blockers, specifically the carboxamides derivatives carbamazepine and oxcarbazepine, are some of the AEDs considered to have a favorable psychiatric effect profile.

OBJECTIVES: We aimed to assess whether the carboxamide analogue eslicarbazepine acetate (ESL) has any effect on the levels of anger in patients with epilepsy. MATERIAL AND METHODS: We prospectively recruited adult patients with epilepsy on treatment with ≦2 active AEDs, who required AED addition or substitution, excluding patients with active psychiatric disorders. All patients completed anger level (STAXI-2), depression-anxiety (HADS), and quality of life (QOLIE-10) assessments, and were evaluated at baseline and within 3 to 6 months after treatment initiation.

RESULTS: 78 patients receiving ESL, as add-on therapy or in substitution of a previous AED, were recruited into the ESL group, with an average age of 48 years and 54% men. We used a control group of 58 patients receiving AEDs other than carboxamides.

CONCLUSIONS: Patients overall showed improvements in anger levels, mood and quality of life during the follow-up. A history of psychiatric disorders was a limiting factor to improve anger levels. As compared to controls, anger levels improved in ESL patients independently from seizure control. Therefore, ESL seems to exert a favorable influence on the anger levels of otherwise healthy patients with epilepsy, including those unresponsive to seizure control. The potential ESL anti-aggressive effect should be studied in patients with epilepsy and active psychiatric disorders. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

Language: en

Keywords

Aggressive behavior; Antiepileptic drugs; Carboxamides; Epilepsy; Eslicarbazepine acetate; anger; behavioral disorders; psychiatric adverse events