Citation

McKeithan L, Hibshman N, Yengo-Kahn AM, Solomon GS, Zuckerman SL. Med. Sci. (Basel) 2019; 7(3): e7030044.

Affiliation

Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA. scott.zuckerman@vumc.org.

Copyright

(Copyright © 2019, MDPI: Multidisciplinary Digital Publishing Institute)

DOI

10.3390/medsci7030044

PMID

30884753

Abstract

Sport-related concussion (SRC) is a highly prevalent injury predominantly affecting millions of youth through high school athletes every year. In recent years, SRC has received a significant amount of attention due to potential for long-term neurologic sequelae. However, the acute symptoms and possibility of prolonged recovery account for the vast majority of morbidity from SRC. Modifying factors have been identified and may allow for improved prediction of a protracted course. Potential novel modifying factors may include genetic determinants of recovery, as well as radiographic biomarkers, which represent burgeoning subfields in SRC research. Helmet design and understanding the biomechanical stressors on the brain that lead to concussion also represent active areas of research. This narrative review provides a general synopsis of SRC, including relevant definitions, current treatment paradigms, and modifying factors for recovery, in addition to novel areas of research and future directions for SRC research.

Language: en

Keywords

biomechanics; genetics; mild traumatic brain injury; neuroimaging; sport-related concussion