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Citation
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Gohar SM, Dieset I, Steen NE, Mørch RH, Vedal TSJ, Reponen EJ, Steen VM, Andreassen OA, Melle I. Acta Psychiatr. Scand. 2019; 139(5): 464-471. |
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Abstract
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OBJECTIVE: Associations between suicidality and lipid dysregulation are documented in mental illness, but the potential role of leptin remains unclear. We examined the association between leptin and suicidal behaviour in schizophrenia, together with the influence of other clinical and biological indices.
METHOD: We recruited a sample of 270 participants with schizophrenia spectrum diagnoses. Blood samples were analysed for leptin, while symptom severity was assessed by Positive and Negative Syndrome Scale (PANSS) and Inventory of Depressive Symptomatology (IDS-C). Patients' history of suicidal behaviour was categorised into three subgroups based on IDS-C suicide subscale: No suicidal behaviour, mild/moderate suicidal behaviour, and severe suicidal behaviour with/without attempts.
RESULTS: Suicidal behaviour was present in 17.4% of mild/moderate group and 34.8% of severe /attempts group. Both groups were significantly associated with female gender (OR=6.0, p=0.004; OR=5.9, p=0.001), lower leptin levels (OR=0.4, p=0.008; OR=0.5, p=0.008) and more severe depression (OR=1.2, p < 0.001; OR=1.1, p < 0.001), respectively. Smoking (OR=2.6, p=0.004), younger age of onset (OR=0.9, p=0.003) and less use of leptin-increasing medications (OR=0.5, p=0.031) were associated with severe/attempts group, while higher C-reactive protein CRP (OR=1.3, p=0.008) was associated with mild/moderate group.
CONCLUSION: Lower leptin levels were associated with higher severity of suicidal behaviour in schizophrenia. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
Language: en |