Citation

Henning K, Teske J, Klintschar M, Dziadosz M. Drug Test. Anal. 2019; 11(4): 626-630.

Affiliation

Hannover Medical School, Germany.

Copyright

(Copyright © 2019, John Wiley and Sons)

DOI

10.1002/dta.2574

PMID

30761754

Abstract

Three cases of fatal intoxication after self-administered pipamperone are reported. The case histories and especially the toxicological findings along with a description of the analytical method are presented. Detection and quantification were performed by liquid chromatography-electrospray-mass spectrometry. Femoral blood concentrations were quantified at 15-39 μg/mL. Besides that, the concentrations of pipamperone in heart blood (15-51 μg/mL), urine (445-548 μg/mL), bile (70-339 μg/mL), liver (91-190 μg/g), kidney (37-74 μg/g), lung (54-227 μg/g) and brain (41-113 μg/g) can be classified as toxic so that the results are most likely in accordance with fatal intoxication especially caused by pipamperone. Besides pipamperone, further pharmaceuticals and ethanol were proven and are stated sorted by the cases. The distribution of pipamperone in the body fluids and tissues is presented. For the first time, this study presents fatal intoxications which were most likely induced by self-administered pipamperone. Furthermore, the data provides a first insight on the distribution of pipamperone.

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Language: en