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Citation
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Wu D, Lu W, Sun X, Wang Y, Xue L, Huang J, Wu Z, Ye C, Wang Y, Song R, Yuan C. Chin. J. Nerv. Ment. Dis. 2018; 44(6): 349-353. |
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Abstract
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OBJECTIVE To investigate the incidence of suicidal ideation and its influencing factors in patients with major depressive disorder.
METHODS Beck scale for suicidal ideation (SSI) was used to evaluate the suicidal ideation of 155 patients with major depressive disorder. The self-made general data questionnaire collected demographic data and used 17 Hamilton depression scale (HAMD-17) and Hamilton anxiety scale (HAMA) to evaluate the factors affecting suicidal ideation. The incidence of suicidal ideation in patients with major depressive disorder was 49.7% (77/155), and that in patients with history of suicide attempt was 17.4% (27/155). Compared with non-Han patients, Han suicidal ideation was stronger (P<0.05). Compared with patients without suicide attempt, patients with suicide attempt had a stronger suicidal ideation (P<0.05); compared with non-suicidal group, HAMD total score, anxiety/somatic factor score, cognition The scores of barrier factors and retardation factors were higher (P<0.05). Path analysis showed that depression (β=0.22, P<0.01), history of attempted suicide (β=0.41, P<0.01) and suspected disease (β= -0.21, P<0.01) has suicidal ideation Predictive effects, anxiety (β=0.08, P<0.01) and suspected disease (β=0.07, P<0.01) all have an indirect effect on suicidal ideation through depression. Bootstrap BC mediation effect test shows that depression in anxiety versus suicidal ideation The effect is completely mediating, and it plays a part in mediating the influence of suspected suicidal ideation.
CONCLUSION The incidence of suicidal ideation in patients with major depressive disorder is high, and the history of suicide attempt and the severity of depression are the main dangers of suicidal ideation. Factors, in the suicide prevention work should pay more attention to patients with suicide attempt and serious depression.
目的 探讨新近缓解的双相障碍患者在参加强化门诊干预项目(intensive outpatient program,IOP)时,情感气质对患者药物依从性的影响.方法 纳入近4个月有一次急性发作而目前处于缓解期的双相障碍患者,按本人对治疗的倾向性分为干预组和对照组,干预组在常规药物干预下同时进行为期约4周共10次IOP干预,对照组仅接受常规药物治疗.使用情感气质自评量表简版评价患者情感气质,治疗前后用药物依从性评价量表评估药物依从性水平,并根据治疗结束时依从性分为高依从性(≥6分)和低依从性(<6分)亚组,探讨情感气质对参加IOP双相障碍患者依从性的影响.结果 治疗结束时高依从性组45例,低依从性组18例.干预组中高、低依从性亚组未治疗时间、抑郁气质得分差异有统计学意义(P<0.05),其他社会人口学因素组间差异均无统计学意义(P>0.05).Logistic回归分析显示IOP干预(OR=6.32,95％CI:1.59～25.14)和抑郁气质(OR=0.71,95％CI:0.52～0.96)影响药物依从性(P<0.05),药物依从性预测模型受试者工作特征曲线的曲线下面积为0.85.分层logistic回归分析示抑郁气质在干预中的调节效应无统计学意义(P=0.06).结论 IOP干预可以改善双相障碍患者药物依从性,而抑郁气质会损害药物依从性.
Language: zh |