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Citation
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Huang Y, Xue Q, Tang Z, Du X, Wang Z, Cao L, Liu Y. Chin. J. Nerv. Ment. Dis. 2018; 44(6): 344-348. |
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Abstract
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OBJECTIVE To explore the effect of meditation and its subtype meditation and reflection on the treatment of patients with first-episode depression with antidepressant therapy.
METHODS: 75 patients with first-episode depression were treated with antidepressant for 8 weeks, and 17 Hamilton depressions were used before and after treatment. The Hamilton depression scale (HAMD) and the contemplative response scale were used to evaluate depressive symptoms and contemplation. According to the degree of depressive symptoms after treatment, the patients were divided into the cured group and the untreated group. The differences between the two groups before and after treatment and the baseline contemplation were compared. The effect on the treatment effect. The results of repeated measures analysis of variance showed that the main effect and time main effect of HAMD, contemplation and meditation were statistically significant (P<0.05), and the cured group was contemplative and meditation before and after treatment. The scores were lower than the untreated group, and the difference was statistically significant (P<0.05). The HAMD, contemplation, meditation and reflection scores of the untreated group and the cured group were lower than those before treatment (P<0.05). Regression analysis showed that the pre-treatment meditation score had a predictive effect on the treatment effect (OR=1.008, 95% CI: 1.017~1.131); the meditation score had a predictive effect on the treatment effect (OR=1.208, 95% CI: 1.06) 5~1.371).
CONCLUSION Contemplation and meditation at baseline have a certain degree of predictive effect on the efficacy of antidepressant therapy in patients with first-episode depression.
目的 探讨沉思及其亚型冥思与反思对首发抑郁症患者接受抗抑郁药物治疗效果的影响.方法纳入75例首发抑郁症患者,接受抗抑郁药物治疗8周,治疗前后均采用17项汉密尔顿抑郁量表(Hamilton depression scale,HAMD)、沉思反应量表对抑郁症状和沉思进行评估,根据治疗后抑郁症状程度分为治愈组与未治愈组,比较两组在治疗前后的沉思差异以及基线期沉思对治疗效果的影响.结果经重复测量方差分析显示,患者HAMD、沉思以及冥思的分组主效应和时间主效应均有统计学意义(P<0.05),其中治愈组在治疗前后沉思及冥思评分均低于未治愈组,差异有统计学意义(P<0.05);未治愈组与治愈组HAMD、沉思、冥思与反思评分在治疗后均较治疗前降低(P<0.05).阶层logistic回归分析示,治疗前沉思得分对治疗效果有预测作用(OR=1.008,95％CI:1.017～1.131);冥思得分对治疗效果有预测作用(OR=1.208,95％CI:1.065～1.371).结论基线期沉思及冥思对首发抑郁症患者接受抗抑郁药物治疗后的疗效有一定程度的预测作用.
Language: zh |