Citation

Trombello JM, Killian MO, Grannemann BD, Rush AJ, Mayes TL, Parsey RV, McInnis M, Jha MK, Ali A, McGrath PJ, Adams P, Oquendo MA, Weissman MM, Carmody TJ, Trivedi MH. J. Psychopharmacol. 2019; 33(2): 185-193.

Affiliation

Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Copyright

(Copyright © 2019, SAGE Publishing)

DOI

10.1177/0269881118817156

PMID

30652941

Abstract

BACKGROUND/AIMS:: While substantial prior research has evaluated the psychometric properties of the 12-item Concise Health Risk Tracking-Self Report (CHRT-SR₁₂), a measure of suicide propensity and suicidal thoughts, no prior research has investigated its factor structure, sensitivity to change over time, and other psychometric properties in a placebo-controlled trial of antidepressant medication, nor determined whether symptoms change throughout treatment.

METHODS:: Participants in the multi-site Establishing Moderators and Biosignatures of Antidepressant Response in Clinical Care (EMBARC) study ( n=278) provided data to evaluate the factor structure and sensitivity to change over time of the CHRT-SR₁₂ through eight weeks of a clinical trial in which participants received either placebo or antidepressant medication (sertraline).

RESULTS/OUTCOMES:: Factor analysis confirmed two factors: propensity (comprised of first-order factors including pessimism, helplessness, social support, and despair) and suicidal thoughts. Internal consistency (α's ranged from 0.69-0.92) and external validity were both acceptable, with the total score and propensity factor scores significantly correlated with total scores and single-item suicidal-thoughts scores on the self-report Quick Inventory of Depressive Symptoms and the clinician-rated 17-item Hamilton Rating Scale for Depression. Through analyzing CHRT-SR₁₂ changes over eight treatment weeks, the total score and both the factors decreased regardless of baseline suicidal thoughts. Change in clinician-rated suicidal thoughts was reflected by change in both the total score and propensity factor score.

CONCLUSIONS/INTERPRETATION:: These results confirm the reliability, validity, and applicability of the CHRT-SR₁₂ to a placebo-controlled clinical trial of depressed outpatients receiving antidepressant medication.

Language: en

Keywords

Concise Health Risk Tracking-Self Report; major depression; psychometrics; suicidal thoughts; suicide ratings