Citation

Carlsen L. Mol. Inform. 2018; ePub(ePub): ePub.

Affiliation

Awareness Center, Linkøpingvej 35, Trekroner, DK-4000, Roskilde, Denmark.

Copyright

(Copyright © 2018, John Wiley and Sons)

DOI

10.1002/minf.201800106

PMID

30474294

Abstract

In March 2018 the term Novichok (Hoвичoκ) became publically known following an attempted murder of a former Russian spy in Salisbury, UK. Novichok is the name of a group of nerve agents secretly produced by Russia in the later stages of the Cold War. These compounds were never declared under the Chemical Weapons Convention and very little is known about the actual identity and characteristics of these compounds. Structures of some of the Novichoks have been reported by a former Russian chemist, Vil Mirzayanov, previously working at the Russian State Scientific Research Institute of Organic Chemistry and Technology (GOSNIIOKhT). It was in this context claimed that at least two compounds of the Novichok family, known as Novichok-5 and Novichok-7 were 5-8 times more potent than the hitherto most toxic nerve agent, VX. The present study elucidates, applying a series of QSAR models toxicity, skin permeation, pharmacokinetic aspects as well as the environmental fate of a series of Novichoks. Virtually the results from the different studies related to human health point in the same direction, i. e., the Novichoks are significantly less toxic than VX and the skin permeation much lower and less efficient than observed for VX. Hence, the claim by Mirzayanov could not be substantiated.

© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Language: en

Keywords

Hydrolysis; Nerve agents; Novichok; QSAR; Skin permeation; Toxicology