Citation

Patel KR, Immaneni S, Singam V, Rastogi S, Silverberg JI. J. Am. Acad. Dermatol. 2019; 80(2): 402-410.

Affiliation

Department of Dermatology, Feinberg School of Medicine at Northwestern University, Chicago, IL USA; Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Feinberg School of Medicine at Northwestern University, Chicago, IL USA; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, IL USA. Electronic address: JonathanISilverberg@Gmail.com.

Copyright

(Copyright © 2019, Elsevier Publishing)

DOI

10.1016/j.jaad.2018.08.063

PMID

30365995

Abstract

BACKGROUND: Atopic dermatitis (AD) is associated with psychological distress. However, previous studies found conflicting results about whether AD is associated with increased depression or suicidality.

OBJECTIVES: To determine the complex relationship between AD and depression.

METHODS: A systematic review was performed of all published observational studies in MEDLINE, Pubmed, EMBASE, GREAT, LILACS, Cochrane Library, Scopus and PsychInfo that analyzed depression in AD. Two reviewers performed study title/abstract review and data abstraction. Pooled meta-analysis was performed using random-effects weighting.

RESULTS: Overall, 106 studies met inclusion criteria; 36 had sufficient data for meta-analysis. The prevalence of any depression was higher in persons with vs. without AD (20.1% vs. 14.8%). Similar results were found in sensitivity analyses of studies assessing clinical depression, depressive symptoms, and adults, with healthy controls, low and high study quality. AD was associated with significantly higher depression scales, parental depression, anti-depressant use, and suicidality. No publication bias was detected LIMITATIONS: Individual level data were not available.

CONCLUSIONS: AD patients have higher odds of depression and suicidality.

Copyright © 2018. Published by Elsevier Inc.

Language: en

Keywords

anti-depressant; atopic dermatitis; comorbidity; depression; eczema; evidence; mood; suicidal ideation; suicide