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Citation
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Guo H, Liu R, Sun Z, Liu B, Xiang Y, Mao J, Li G, Zhang M. World Neurosurg. 2019; 121: e630-e639. |
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Affiliation
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Department of Neurosurgery, Harrison International Peace Hospital, Hebei Medical University, Hebei, China. Electronic address: 66364321@qq.com. |
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Abstract
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BACKGROUND: Our study is aimed to investigate the change of the default-mode network (DMN) by using Amplitude of Low-Frequency Fluctuation (ALFF) and functional connectivity (FC) methods in acute phase patients after severe traumatic brain injury (sTBI) and to correlate these changes with its prognosis.
METHODS: Twenty one patients with severe traumatic brain injury were included in this study. Gender, age and education matched controls were participated in this study. Twenty-one healthy volunteers were recruited for the control group. Of 21 patients, 12 patients regained consciousness (GOS > 2) and 9 patients remained unconscious (GOS < 2). The FC and ALFF values were measured in DMN and compared between the groups. We further assessed and compared the FC and ALFF value in both group.
RESULTS: sTBI patients showed significantly decreased functional connectivity and ALFF values in the DMN. While, patient with better prognosis showed a significant increased in the functional connectivity and ALFF values in DMN. The conscious subgroup showed significantly enhanced functional connectivity in the medial superior frontal gyrus, left temporal gyrus, anterior cingulate gyrus, precuneus, posterior cingulate gyrus, and parietal cortex compared to the coma subgroup. Increased ALFF values in the right frontal gyrus, right temporal gyrus, and right inferior parietal gyrus was significantly showed in the conscious subgroup compared to the coma subgroup.
CONCLUSION: Increased in the functional connectivity and ALFF values in the DMN is related to better prognosis in patient with severe traumatic brain injury.
Copyright © 2018. Published by Elsevier Inc.
Language: en |