Citation

Lin CH, Faisal AA. Sci. Rep. 2018; 8(1): e14546.

Affiliation

MRC London Institute of Medical Sciences, W12 0NN, London, UK. a.faisal@imperial.ac.uk.

Copyright

(Copyright © 2018, Nature Publishing Group)

DOI

10.1038/s41598-018-32648-z

PMID

30267026

Abstract

The relationship between sensorimotor variability and falls in older people has not been well investigated. We developed a novel task having shared biomechanics of obstacle negotiation to quantify sensorimotor variability related to locomotion across age. We found that sensorimotor variability in foot placement increases continuously with age. We then applied sensory psychophysics to pinpoint the visual and somatosensory systems associated with sensorimotor variability. We showed increased sensory variability, specifically increased proprioceptive variability, the vital cause of more variable foot placement in older people (greater than 65 years). Notably, older participants relied more on the vision to judge their own foot's height compared to the young, suggesting a shift in multisensory integration strategy to compensate for degenerated proprioception. We further modelled the probability of tripping-over based on the relationship between sensorimotor variability and age and found a correspondence between model prediction and community-based data. We reveal increased sensorimotor variability, modulated by sensation precision, a potentially vital mechanism of raised tripping-over and thus fall events in older people. Analysis of sensorimotor variability and its specific components may have the utility of fall risk and rehabilitation target evaluation.

Language: en