Citation

Weigl J, Vloet T, Egberts K, Briegel W, Kratz J, Romanos M, Gerlach M. Z. Kinder Jugendpsychiatr Psychother. 2019; 47(2): 168-170.

Affiliation

University Hospital of Würzburg, Center of Mental Health, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Würzburg, Germany.

Copyright

(Copyright © 2019, Verlag Hans Huber)

DOI

10.1024/1422-4917/a000613

PMID

30185094

Abstract

The use of selective serotonin reuptake inhibitors (SSRIs) like citalopram in the clinical treatment of depressive symptoms in children and adolescents has become increasingly common, although application is mostly off-label. The increasing number of prescriptions is not only due to their good efficacy, but also due to their good tolerability and the comparatively low risk in cases of intoxication. However, there is discussion about the cardiac safety of overdose ingestion of citalopram. Here, we report in detail on an adolescent with depressive symptoms who used 800 mg of citalopram in order to attempt suicide. In contrast to other case reports in adults, our patient showed only mild neurological symptoms and no cardiac toxicity or symptoms of a serotonin syndrome, despite a high citalopram blood concentration measured about two hours following ingestion of citalopram (633 ng/ml; therapeutic reference range for adults 50-110 ng/ml).

Language: en

Keywords

Antidepressiva; Citalopram; Intoxikation; SSRIs; Suizidversuch; adverse drug reactions; antidepressants; intoxication; suicide attempt; unerwünschte Arzneimittelwirkung